Drug interactions
Clomipramine + Solifenacin
Severity: Moderate
Clomipramine and Solifenacin: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Clomipramine has marked anticholinergic activity that adds to solifenacin, increasing the risk of urinary retention, constipation, dry mouth, confusion, and tachycardia. Both drugs may also prolong the QT interval.
What this interaction means in plain words
Clomipramine and Solifenacin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Clomipramine belongs to Central Nervous System; Solifenacin belongs to Genitourinary.
Why it happens
Additive antimuscarinic effects and additive QT prolongation.
What to do
Monitor for anticholinergic toxicity and consider an ECG in patients with cardiac risk factors. Prefer an alternative in older patients.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Solifenacin
Other interactions of Clomipramine
- Arsenic trioxide + Clomipramine Contraindicated
- Clomipramine + Dofetilide Contraindicated
- Clomipramine + Droperidol Contraindicated
- Clomipramine + Isocarboxazid Contraindicated
- Clomipramine + Methylene blue Contraindicated
- Clomipramine + Pentamidine Contraindicated
Frequently asked questions
Can I take Clomipramine with Solifenacin?
MediHelp rates the interaction as moderate. Clomipramine and Solifenacin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Clomipramine has marked anticholinergic activity that adds to solifenacin, increasing the risk of urinary retention, constipation, dry mouth, confusion, and tachycardia. Both drugs may also prolong the QT interval.
How serious is the interaction between Clomipramine and Solifenacin?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor for anticholinergic toxicity and consider an ECG in patients with cardiac risk factors. Prefer an alternative in older patients.
What other medicines interact with Solifenacin?
MediHelp also lists interactions of Solifenacin with, for example, Adagrasib, Amiodarone, Amisulpride. The full list is on the Solifenacin page.
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