Drug interactions
Clomipramine + Temazepam
Severity: Moderate
Clomipramine and Temazepam: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Both drugs cause sedation, so combined use increases drowsiness, psychomotor impairment and fall risk, particularly in older adults. Respiratory depression is less likely but possible with overdose.
What this interaction means in plain words
Clomipramine and Temazepam can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Clomipramine belongs to Central Nervous System; Temazepam belongs to Central Nervous System.
Why it happens
Additive CNS depression.
What to do
Use the lowest effective doses and monitor for excess sedation and impaired coordination. Warn patients about driving and alcohol, and be especially careful in elderly patients.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Clomipramine
- Arsenic trioxide + Clomipramine Contraindicated
- Clomipramine + Dofetilide Contraindicated
- Clomipramine + Droperidol Contraindicated
- Clomipramine + Isocarboxazid Contraindicated
- Clomipramine + Methylene blue Contraindicated
- Clomipramine + Pentamidine Contraindicated
Other interactions of Temazepam
- Alprazolam + Temazepam Major
- Amobarbital + Temazepam Major
- Buprenorphine + Temazepam Major
- Butorphanol + Temazepam Major
- Carisoprodol + Temazepam Major
- Chloral hydrate + Temazepam Major
Frequently asked questions
Can I take Clomipramine with Temazepam?
MediHelp rates the interaction as moderate. Clomipramine and Temazepam can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Both drugs cause sedation, so combined use increases drowsiness, psychomotor impairment and fall risk, particularly in older adults. Respiratory depression is less likely but possible with overdose.
How serious is the interaction between Clomipramine and Temazepam?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Use the lowest effective doses and monitor for excess sedation and impaired coordination. Warn patients about driving and alcohol, and be especially careful in elderly patients.
What other medicines interact with Clomipramine?
MediHelp also lists interactions of Clomipramine with, for example, Arsenic trioxide, Dofetilide, Droperidol. The full list is on the Clomipramine page.
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