Drug interactions
Clomipramine + Trimethoprim
Severity: Minor
Clomipramine and Trimethoprim: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Trimethoprim has limited reports of QT prolongation and may add modestly to the effect of clomipramine. Risk is mainly relevant in patients with other QT risk factors.
What this interaction means in plain words
Clomipramine and Trimethoprim have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Clomipramine belongs to Central Nervous System; Trimethoprim belongs to Anti Bacterial.
Why it happens
Possible additive QTc prolongation; the evidence for trimethoprim is limited.
What to do
Consider an ECG and electrolyte check in patients with heart disease, electrolyte disturbance or other QT-prolonging drugs. Otherwise no change is needed.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Clomipramine
- Arsenic trioxide + Clomipramine Contraindicated
- Clomipramine + Dofetilide Contraindicated
- Clomipramine + Droperidol Contraindicated
- Clomipramine + Isocarboxazid Contraindicated
- Clomipramine + Methylene blue Contraindicated
- Clomipramine + Pentamidine Contraindicated
Other interactions of Trimethoprim
Frequently asked questions
Can I take Clomipramine with Trimethoprim?
MediHelp rates the interaction as minor. Clomipramine and Trimethoprim have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Trimethoprim has limited reports of QT prolongation and may add modestly to the effect of clomipramine. Risk is mainly relevant in patients with other QT risk factors.
How serious is the interaction between Clomipramine and Trimethoprim?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Consider an ECG and electrolyte check in patients with heart disease, electrolyte disturbance or other QT-prolonging drugs. Otherwise no change is needed.
What other medicines interact with Clomipramine?
MediHelp also lists interactions of Clomipramine with, for example, Arsenic trioxide, Dofetilide, Droperidol. The full list is on the Clomipramine page.
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