Drug interactions
Clonazepam + Enzalutamide
Severity: Moderate
Clonazepam and Enzalutamide: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Enzalutamide is a strong CYP3A4 inducer and can lower clonazepam concentrations. This may reduce seizure or panic control, and withdrawal symptoms may emerge when induction develops.
What this interaction means in plain words
Clonazepam and Enzalutamide can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Clonazepam belongs to Central Nervous System; Enzalutamide belongs to Endocrine.
Why it happens
Induction of hepatic and intestinal CYP3A4 by enzalutamide accelerates clonazepam metabolism.
What to do
Monitor for loss of clonazepam efficacy and increase the dose if needed. Reassess the dose after enzalutamide is stopped because the induction wears off slowly.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Clonazepam
- Calcium / magnesium / potassium / sodium oxybates + Clonazepam Contraindicated
- Clonazepam + Sodium oxybate Contraindicated
- Alfentanil + Clonazepam Major
- Alprazolam + Clonazepam Major
- Amobarbital + Clonazepam Major
- Belladonna and opium + Clonazepam Major
Other interactions of Enzalutamide
- Doravirine + Enzalutamide Contraindicated
- Elbasvir / grazoprevir + Enzalutamide Contraindicated
- Ensitrelvir + Enzalutamide Contraindicated
- Enzalutamide + Fostemsavir Contraindicated
- Enzalutamide + Isavuconazonium Contraindicated
- Enzalutamide + Lenacapavir Contraindicated
Frequently asked questions
Can I take Clonazepam with Enzalutamide?
MediHelp rates the interaction as moderate. Clonazepam and Enzalutamide can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Enzalutamide is a strong CYP3A4 inducer and can lower clonazepam concentrations. This may reduce seizure or panic control, and withdrawal symptoms may emerge when induction develops.
How serious is the interaction between Clonazepam and Enzalutamide?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor for loss of clonazepam efficacy and increase the dose if needed. Reassess the dose after enzalutamide is stopped because the induction wears off slowly.
What other medicines interact with Clonazepam?
MediHelp also lists interactions of Clonazepam with, for example, Calcium / magnesium / potassium / sodium oxybates, Sodium oxybate, Alfentanil. The full list is on the Clonazepam page.
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