Drug interactions
Clonazepam + Lisdexamfetamine
Severity: Minor
Clonazepam and Lisdexamfetamine: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
The stimulant may mask clonazepam drowsiness without reversing its effect on cognition and coordination. The net effect is unpredictable, and the two drugs oppose each other in anxiety and sleep.
What this interaction means in plain words
Clonazepam and Lisdexamfetamine have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Clonazepam belongs to Central Nervous System; Lisdexamfetamine belongs to Central Nervous System.
Why it happens
Opposing pharmacodynamic effects of CNS stimulation and GABAergic depression; no established pharmacokinetic interaction.
What to do
No dose change is generally needed. Advise patients not to assume they are alert enough to drive just because they are taking the stimulant.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Clonazepam
- Calcium / magnesium / potassium / sodium oxybates + Clonazepam Contraindicated
- Clonazepam + Sodium oxybate Contraindicated
- Alfentanil + Clonazepam Major
- Alprazolam + Clonazepam Major
- Amobarbital + Clonazepam Major
- Belladonna and opium + Clonazepam Major
Other interactions of Lisdexamfetamine
- Isocarboxazid + Lisdexamfetamine Contraindicated
- Linezolid + Lisdexamfetamine Contraindicated
- Lisdexamfetamine + Phenelzine Contraindicated
- Lisdexamfetamine + Procarbazine Contraindicated
- Lisdexamfetamine + Rasagiline Contraindicated
- Lisdexamfetamine + Safinamide Contraindicated
Frequently asked questions
Can I take Clonazepam with Lisdexamfetamine?
MediHelp rates the interaction as minor. Clonazepam and Lisdexamfetamine have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. The stimulant may mask clonazepam drowsiness without reversing its effect on cognition and coordination. The net effect is unpredictable, and the two drugs oppose each other in anxiety and sleep.
How serious is the interaction between Clonazepam and Lisdexamfetamine?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: No dose change is generally needed. Advise patients not to assume they are alert enough to drive just because they are taking the stimulant.
What other medicines interact with Clonazepam?
MediHelp also lists interactions of Clonazepam with, for example, Calcium / magnesium / potassium / sodium oxybates, Sodium oxybate, Alfentanil. The full list is on the Clonazepam page.
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