Drug interactions
Clonazepam + Perampanel
Severity: Moderate
Clonazepam and Perampanel: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Perampanel can cause dizziness, somnolence and impaired coordination, and these effects add to benzodiazepine sedation. Perampanel is also associated with mood and behavioral changes, which may complicate the clinical picture.
What this interaction means in plain words
Clonazepam and Perampanel can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Clonazepam belongs to Central Nervous System; Perampanel belongs to Central Nervous System.
Why it happens
Additive CNS depression; perampanel is an AMPA receptor antagonist and clonazepam enhances GABA-A activity.
What to do
Titrate perampanel slowly and monitor for somnolence, ataxia and falls. Counsel patients on driving and operating machinery.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Clonazepam
- Calcium / magnesium / potassium / sodium oxybates + Clonazepam Contraindicated
- Clonazepam + Sodium oxybate Contraindicated
- Alfentanil + Clonazepam Major
- Alprazolam + Clonazepam Major
- Amobarbital + Clonazepam Major
- Belladonna and opium + Clonazepam Major
Other interactions of Perampanel
- Apalutamide + Perampanel Major
- Enzalutamide + Perampanel Major
- Alprazolam + Perampanel Moderate
- Amisulpride + Perampanel Moderate
- Amobarbital + Perampanel Moderate
- Asenapine + Perampanel Moderate
Frequently asked questions
Can I take Clonazepam with Perampanel?
MediHelp rates the interaction as moderate. Clonazepam and Perampanel can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Perampanel can cause dizziness, somnolence and impaired coordination, and these effects add to benzodiazepine sedation. Perampanel is also associated with mood and behavioral changes, which may complicate the clinical picture.
How serious is the interaction between Clonazepam and Perampanel?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Titrate perampanel slowly and monitor for somnolence, ataxia and falls. Counsel patients on driving and operating machinery.
What other medicines interact with Clonazepam?
MediHelp also lists interactions of Clonazepam with, for example, Calcium / magnesium / potassium / sodium oxybates, Sodium oxybate, Alfentanil. The full list is on the Clonazepam page.
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