Drug interactions
Clonazepam + Propofol
Severity: Major
Clonazepam and Propofol: major interaction.
Last updated Sources: UK SmPC
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Benzodiazepines potentiate the sedative and hypnotic effects of propofol, so lower propofol doses are needed to reach the same depth of anesthesia. Combined use increases the risk of hypotension, apnea and airway compromise.
What this interaction means in plain words
Clonazepam and Propofol can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Clonazepam belongs to Central Nervous System; Propofol belongs to Central Nervous System.
Why it happens
Synergistic GABA-A receptor potentiation by propofol and the benzodiazepine.
What to do
Reduce propofol doses and titrate slowly to effect in patients taking clonazepam. Ensure continuous monitoring of ventilation, oxygenation and blood pressure by trained staff.
What to ask your pharmacist
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
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References
Other interactions of Clonazepam
- Calcium / magnesium / potassium / sodium oxybates + Clonazepam Contraindicated
- Clonazepam + Sodium oxybate Contraindicated
- Alfentanil + Clonazepam Major
- Alprazolam + Clonazepam Major
- Amobarbital + Clonazepam Major
- Belladonna and opium + Clonazepam Major
Other interactions of Propofol
Frequently asked questions
Can I take Clonazepam with Propofol?
MediHelp rates the interaction as major. Clonazepam and Propofol can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Benzodiazepines potentiate the sedative and hypnotic effects of propofol, so lower propofol doses are needed to reach the same depth of anesthesia. Combined use increases the risk of hypotension, apnea and airway compromise.
How serious is the interaction between Clonazepam and Propofol?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Reduce propofol doses and titrate slowly to effect in patients taking clonazepam. Ensure continuous monitoring of ventilation, oxygenation and blood pressure by trained staff.
What other medicines interact with Clonazepam?
MediHelp also lists interactions of Clonazepam with, for example, Calcium / magnesium / potassium / sodium oxybates, Sodium oxybate, Alfentanil. The full list is on the Clonazepam page.
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