Drug interactions
Clonidine + Ertugliflozin-sitagliptin
Severity: Minor
Clonidine and Ertugliflozin-sitagliptin: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Clonidine may blunt the adrenergic warning symptoms of hypoglycemia such as tremor and palpitations. Hypoglycemia can therefore go unrecognized, although sitagliptin and ertugliflozin alone carry low hypoglycemia risk.
What this interaction means in plain words
Clonidine and Ertugliflozin-sitagliptin have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Clonidine belongs to Cardiovascular; Ertugliflozin-sitagliptin belongs to Endocrine.
Why it happens
Central sympatholytic action reduces catecholamine-mediated hypoglycemia symptoms.
What to do
Counsel patients that hypoglycemia symptoms may be masked and monitor blood glucose, particularly if insulin or a sulfonylurea is also used.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
Pro+ members
Unlock the full page
Create an account and start a Pro+ trial to unlock the full management advice for Clonidine and Ertugliflozin-sitagliptin, the additional notes, the evidence detail and the whole-prescription interaction checker.
- Full clinical management advice
- Additional notes
- Evidence detail
- Interaction checker for a whole prescription
Try Pro+ free for 7 days on the web. No card needed.
Other interactions of Ertugliflozin-sitagliptin
Other interactions of Clonidine
- Acebutolol + Clonidine Major
- Amifostine + Clonidine Major
- Amiodarone + Clonidine Major
- Amoxapine + Clonidine Major
- Atenolol-chlorthalidone + Clonidine Major
- Atenolol + Clonidine Major
Frequently asked questions
Can I take Clonidine with Ertugliflozin-sitagliptin?
MediHelp rates the interaction as minor. Clonidine and Ertugliflozin-sitagliptin have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Clonidine may blunt the adrenergic warning symptoms of hypoglycemia such as tremor and palpitations. Hypoglycemia can therefore go unrecognized, although sitagliptin and ertugliflozin alone carry low hypoglycemia risk.
How serious is the interaction between Clonidine and Ertugliflozin-sitagliptin?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Counsel patients that hypoglycemia symptoms may be masked and monitor blood glucose, particularly if insulin or a sulfonylurea is also used.
What other medicines interact with Ertugliflozin-sitagliptin?
MediHelp also lists interactions of Ertugliflozin-sitagliptin with, for example, Albiglutide, Aripiprazole, Asenapine. The full list is on the Ertugliflozin-sitagliptin page.
Full monographs, dosing and an interaction checker in the MediHelp app
Open the complete reference, check multi-drug interactions and use dosing tools in the MediHelp app.
