Drug interactions
Clonidine + Rolapitant
Severity: Minor
Clonidine and Rolapitant: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Oral rolapitant inhibits intestinal P-glycoprotein, which may raise levels of P-gp substrates. Clonidine is a P-gp substrate in part, so exposure may rise modestly, causing bradycardia, hypotension and sedation.
What this interaction means in plain words
Clonidine and Rolapitant have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Clonidine belongs to Cardiovascular; Rolapitant belongs to Gastrointestinal Tract.
Why it happens
Rolapitant inhibits P-glycoprotein efflux, potentially increasing clonidine absorption and exposure.
What to do
Monitor blood pressure and heart rate if used together, and reduce clonidine if hypotension or bradycardia occurs.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Rolapitant
- Pimozide + Rolapitant Contraindicated
- Rolapitant + Thioridazine Contraindicated
- Atomoxetine + Rolapitant Major
- Deutetrabenazine + Rolapitant Major
- Eliglustat + Rolapitant Major
- Flecainide + Rolapitant Major
Other interactions of Clonidine
- Acebutolol + Clonidine Major
- Amifostine + Clonidine Major
- Amiodarone + Clonidine Major
- Amoxapine + Clonidine Major
- Atenolol-chlorthalidone + Clonidine Major
- Atenolol + Clonidine Major
Frequently asked questions
Can I take Clonidine with Rolapitant?
MediHelp rates the interaction as minor. Clonidine and Rolapitant have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Oral rolapitant inhibits intestinal P-glycoprotein, which may raise levels of P-gp substrates. Clonidine is a P-gp substrate in part, so exposure may rise modestly, causing bradycardia, hypotension and sedation.
How serious is the interaction between Clonidine and Rolapitant?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor blood pressure and heart rate if used together, and reduce clonidine if hypotension or bradycardia occurs.
What other medicines interact with Rolapitant?
MediHelp also lists interactions of Rolapitant with, for example, Pimozide, Thioridazine, Atomoxetine. The full list is on the Rolapitant page.
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