Drug interactions
Clopidogrel + Defibrotide
Severity: Moderate
Clopidogrel and Defibrotide: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Defibrotide has profibrinolytic and antithrombotic activity, and combining it with an antiplatelet such as clopidogrel may increase the risk of bleeding. Defibrotide labeling advises against concurrent use with systemic anticoagulants or fibrinolytics, and caution applies with other agents affecting hemostasis.
What this interaction means in plain words
Clopidogrel and Defibrotide can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Clopidogrel belongs to Cardiovascular; Defibrotide belongs to Cardiovascular.
Why it happens
Additive pharmacodynamic effects on hemostasis from platelet P2Y12 inhibition and defibrotide's profibrinolytic activity.
What to do
Monitor for signs of bleeding and check hemoglobin and coagulation parameters regularly. Consider whether clopidogrel can be held during defibrotide therapy if bleeding occurs.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Clopidogrel
Other interactions of Defibrotide
- Alteplase + Defibrotide Contraindicated
- Apixaban + Defibrotide Contraindicated
- Argatroban + Defibrotide Contraindicated
- Dabigatran etexilate + Defibrotide Contraindicated
- Dalteparin + Defibrotide Contraindicated
- Defibrotide + Edoxaban Contraindicated
Frequently asked questions
Can I take Clopidogrel with Defibrotide?
MediHelp rates the interaction as moderate. Clopidogrel and Defibrotide can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Defibrotide has profibrinolytic and antithrombotic activity, and combining it with an antiplatelet such as clopidogrel may increase the risk of bleeding. Defibrotide labeling advises against concurrent use with systemic anticoagulants or fibrinolytics, and caution applies with other agents affecting hemostasis.
How serious is the interaction between Clopidogrel and Defibrotide?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor for signs of bleeding and check hemoglobin and coagulation parameters regularly. Consider whether clopidogrel can be held during defibrotide therapy if bleeding occurs.
What other medicines interact with Clopidogrel?
MediHelp also lists interactions of Clopidogrel with, for example, Ombitasvir / paritaprevir / ritonavir and dasabuvir, Abrocitinib, Acetylsalicylic acid. The full list is on the Clopidogrel page.
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