Drug interactions
Clopidogrel + Fluconazole
Severity: Moderate
Clopidogrel and Fluconazole: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Fluconazole inhibits CYP2C19, which is needed to activate clopidogrel. Less active metabolite is formed, so platelet inhibition may be weaker and the protection against thrombotic events, particularly after stenting, may be reduced.
What this interaction means in plain words
Clopidogrel and Fluconazole can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Clopidogrel belongs to Cardiovascular; Fluconazole belongs to Anti Fungals.
Why it happens
Inhibition of CYP2C19-mediated bioactivation of clopidogrel.
What to do
Avoid the combination when feasible, especially in high-risk patients such as those with recent stents. Consider an alternative antifungal or an antiplatelet not dependent on CYP2C19.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Fluconazole
- Dihydroergotamine intranasal + Fluconazole Contraindicated
- Dihydroergotamine + Fluconazole Contraindicated
- Dofetilide + Fluconazole Contraindicated
- Domperidone + Fluconazole Contraindicated
- Dronedarone + Fluconazole Contraindicated
- Erythromycin + Fluconazole Contraindicated
Other interactions of Clopidogrel
Frequently asked questions
Can I take Clopidogrel with Fluconazole?
MediHelp rates the interaction as moderate. Clopidogrel and Fluconazole can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Fluconazole inhibits CYP2C19, which is needed to activate clopidogrel. Less active metabolite is formed, so platelet inhibition may be weaker and the protection against thrombotic events, particularly after stenting, may be reduced.
How serious is the interaction between Clopidogrel and Fluconazole?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid the combination when feasible, especially in high-risk patients such as those with recent stents. Consider an alternative antifungal or an antiplatelet not dependent on CYP2C19.
What other medicines interact with Fluconazole?
MediHelp also lists interactions of Fluconazole with, for example, Dihydroergotamine intranasal, Dihydroergotamine, Dofetilide. The full list is on the Fluconazole page.
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