Drug interactions
Clopidogrel + Levoketoconazole
Severity: Moderate
Clopidogrel and Levoketoconazole: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Levoketoconazole inhibits CYP2C19 and CYP3A4, both involved in clopidogrel activation, so antiplatelet effect may be reduced. This is relevant in patients needing reliable platelet inhibition.
What this interaction means in plain words
Clopidogrel and Levoketoconazole can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Clopidogrel belongs to Cardiovascular; Levoketoconazole belongs to Endocrine.
Why it happens
Inhibition of CYP2C19 and CYP3A4 reduces bioactivation of clopidogrel.
What to do
Consider an alternative P2Y12 inhibitor not reliant on these enzymes, such as ticagrelor, if clinically suitable. Otherwise monitor for ischemic events.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Clopidogrel
Other interactions of Levoketoconazole
- Alfuzosin + Levoketoconazole Contraindicated
- Alprazolam + Levoketoconazole Contraindicated
- Amiodarone + Levoketoconazole Contraindicated
- Avanafil + Levoketoconazole Contraindicated
- Cisapride + Levoketoconazole Contraindicated
- Clarithromycin + Levoketoconazole Contraindicated
Frequently asked questions
Can I take Clopidogrel with Levoketoconazole?
MediHelp rates the interaction as moderate. Clopidogrel and Levoketoconazole can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Levoketoconazole inhibits CYP2C19 and CYP3A4, both involved in clopidogrel activation, so antiplatelet effect may be reduced. This is relevant in patients needing reliable platelet inhibition.
How serious is the interaction between Clopidogrel and Levoketoconazole?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Consider an alternative P2Y12 inhibitor not reliant on these enzymes, such as ticagrelor, if clinically suitable. Otherwise monitor for ischemic events.
What other medicines interact with Clopidogrel?
MediHelp also lists interactions of Clopidogrel with, for example, Ombitasvir / paritaprevir / ritonavir and dasabuvir, Abrocitinib, Acetylsalicylic acid. The full list is on the Clopidogrel page.
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