Drug interactions
Clopidogrel + Modafinil
Severity: Minor
Clopidogrel and Modafinil: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Modafinil is a weak inhibitor of CYP2C19 and may modestly reduce clopidogrel activation. Clinical significance is uncertain and likely small in most patients.
What this interaction means in plain words
Clopidogrel and Modafinil have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Clopidogrel belongs to Cardiovascular; Modafinil belongs to Central Nervous System.
Why it happens
Weak CYP2C19 inhibition may slightly reduce formation of the active metabolite of clopidogrel.
What to do
Usually no change is needed; be aware in patients at high thrombotic risk such as recent stenting and consider alternatives if concerns arise.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Clopidogrel
Other interactions of Modafinil
Frequently asked questions
Can I take Clopidogrel with Modafinil?
MediHelp rates the interaction as minor. Clopidogrel and Modafinil have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Modafinil is a weak inhibitor of CYP2C19 and may modestly reduce clopidogrel activation. Clinical significance is uncertain and likely small in most patients.
How serious is the interaction between Clopidogrel and Modafinil?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Usually no change is needed; be aware in patients at high thrombotic risk such as recent stenting and consider alternatives if concerns arise.
What other medicines interact with Clopidogrel?
MediHelp also lists interactions of Clopidogrel with, for example, Ombitasvir / paritaprevir / ritonavir and dasabuvir, Abrocitinib, Acetylsalicylic acid. The full list is on the Clopidogrel page.
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