Drug interactions
Clopidogrel + Stiripentol
Severity: Moderate
Clopidogrel and Stiripentol: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Stiripentol inhibits CYP2C19, which is required to convert clopidogrel to its active form, and clopidogrel's antiplatelet effect may be diminished. This might raise the risk of thrombotic events.
What this interaction means in plain words
Clopidogrel and Stiripentol can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Clopidogrel belongs to Cardiovascular; Stiripentol belongs to Central Nervous System.
Why it happens
Inhibition of CYP2C19 by stiripentol reduces bioactivation of clopidogrel.
What to do
Consider an antiplatelet agent less dependent on CYP2C19 in patients at high thrombotic risk. Otherwise, monitor for thrombotic events.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Stiripentol
Other interactions of Clopidogrel
Frequently asked questions
Can I take Clopidogrel with Stiripentol?
MediHelp rates the interaction as moderate. Clopidogrel and Stiripentol can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Stiripentol inhibits CYP2C19, which is required to convert clopidogrel to its active form, and clopidogrel's antiplatelet effect may be diminished. This might raise the risk of thrombotic events.
How serious is the interaction between Clopidogrel and Stiripentol?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Consider an antiplatelet agent less dependent on CYP2C19 in patients at high thrombotic risk. Otherwise, monitor for thrombotic events.
What other medicines interact with Stiripentol?
MediHelp also lists interactions of Stiripentol with, for example, Apalutamide, Clomipramine, Ergotamine. The full list is on the Stiripentol page.
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