Drug interactions
Clopidogrel + Vortioxetine
Severity: Moderate
Clopidogrel and Vortioxetine: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Vortioxetine inhibits serotonin reuptake and can impair platelet function, thereby adding to clopidogrel's bleeding risk. Case reports and class data indicate an increased tendency to bruising and GI bleeding.
What this interaction means in plain words
Clopidogrel and Vortioxetine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Clopidogrel belongs to Cardiovascular; Vortioxetine belongs to Central Nervous System.
Why it happens
Additive pharmacodynamic effect: reduced platelet serotonin uptake impairs aggregation alongside P2Y12 inhibition.
What to do
Monitor for signs of bleeding and consider gastroprotection in patients with GI risk factors.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Clopidogrel
Other interactions of Vortioxetine
- Isocarboxazid + Vortioxetine Contraindicated
- Linezolid + Vortioxetine Contraindicated
- Methylene blue + Vortioxetine Contraindicated
- Phenelzine + Vortioxetine Contraindicated
- Rasagiline + Vortioxetine Contraindicated
- Selegiline transdermal + Vortioxetine Contraindicated
Frequently asked questions
Can I take Clopidogrel with Vortioxetine?
MediHelp rates the interaction as moderate. Clopidogrel and Vortioxetine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Vortioxetine inhibits serotonin reuptake and can impair platelet function, thereby adding to clopidogrel's bleeding risk. Case reports and class data indicate an increased tendency to bruising and GI bleeding.
How serious is the interaction between Clopidogrel and Vortioxetine?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor for signs of bleeding and consider gastroprotection in patients with GI risk factors.
What other medicines interact with Clopidogrel?
MediHelp also lists interactions of Clopidogrel with, for example, Ombitasvir / paritaprevir / ritonavir and dasabuvir, Abrocitinib, Acetylsalicylic acid. The full list is on the Clopidogrel page.
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