Drug interactions
Clorazepate + Darunavir
Severity: Moderate
Clorazepate and Darunavir: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Boosted darunavir may increase concentrations of clorazepate's active metabolite and cause more sedation. Respiratory depression is possible at high doses.
What this interaction means in plain words
Clorazepate and Darunavir can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Clorazepate belongs to Central Nervous System; Darunavir belongs to Anti Virals.
Why it happens
Darunavir with ritonavir or cobicistat inhibits CYP3A4, reducing clearance of nordiazepam.
What to do
Monitor for oversedation and consider reducing the clorazepate dose. Lorazepam is an alternative that avoids CYP3A4-based interaction.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Clorazepate
- Calcium / magnesium / potassium / sodium oxybates + Clorazepate Contraindicated
- Clorazepate + Sodium oxybate Contraindicated
- Alfentanil + Clorazepate Major
- Alprazolam + Clorazepate Major
- Amobarbital + Clorazepate Major
- Belladonna and opium + Clorazepate Major
Other interactions of Darunavir
- Alfuzosin + Darunavir Contraindicated
- Avanafil + Darunavir Contraindicated
- Darunavir + Dronedarone Contraindicated
- Darunavir + Eletriptan Contraindicated
- Darunavir + Ergotamine Contraindicated
- Darunavir + Flibanserin Contraindicated
Frequently asked questions
Can I take Clorazepate with Darunavir?
MediHelp rates the interaction as moderate. Clorazepate and Darunavir can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Boosted darunavir may increase concentrations of clorazepate's active metabolite and cause more sedation. Respiratory depression is possible at high doses.
How serious is the interaction between Clorazepate and Darunavir?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor for oversedation and consider reducing the clorazepate dose. Lorazepam is an alternative that avoids CYP3A4-based interaction.
What other medicines interact with Clorazepate?
MediHelp also lists interactions of Clorazepate with, for example, Calcium / magnesium / potassium / sodium oxybates, Sodium oxybate, Alfentanil. The full list is on the Clorazepate page.
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