Drug interactions
Clorazepate + Desflurane
Severity: Moderate
Clorazepate and Desflurane: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Benzodiazepines such as clorazepate reduce the anesthetic requirement for inhaled agents and enhance sedation and respiratory depression. Recovery from anesthesia may be prolonged.
What this interaction means in plain words
Clorazepate and Desflurane can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Clorazepate belongs to Central Nervous System; Desflurane belongs to Central Nervous System.
Why it happens
Additive CNS depression through enhancement of GABA-A receptor activity by both agents.
What to do
The anesthesia team should titrate desflurane to effect, monitor depth of anesthesia and ventilation, and expect a possibly slower emergence. Continue chronic benzodiazepine therapy perioperatively to avoid withdrawal.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
Pro+ members
Unlock the full page
Create an account and start a Pro+ trial to unlock the full management advice for Clorazepate and Desflurane, the additional notes, the evidence detail and the whole-prescription interaction checker.
- Full clinical management advice
- Additional notes
- Evidence detail
- Interaction checker for a whole prescription
Try Pro+ free for 7 days on the web. No card needed.
Other interactions of Clorazepate
- Calcium / magnesium / potassium / sodium oxybates + Clorazepate Contraindicated
- Clorazepate + Sodium oxybate Contraindicated
- Alfentanil + Clorazepate Major
- Alprazolam + Clorazepate Major
- Amobarbital + Clorazepate Major
- Belladonna and opium + Clorazepate Major
Other interactions of Desflurane
Frequently asked questions
Can I take Clorazepate with Desflurane?
MediHelp rates the interaction as moderate. Clorazepate and Desflurane can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Benzodiazepines such as clorazepate reduce the anesthetic requirement for inhaled agents and enhance sedation and respiratory depression. Recovery from anesthesia may be prolonged.
How serious is the interaction between Clorazepate and Desflurane?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: The anesthesia team should titrate desflurane to effect, monitor depth of anesthesia and ventilation, and expect a possibly slower emergence. Continue chronic benzodiazepine therapy perioperatively to avoid withdrawal.
What other medicines interact with Clorazepate?
MediHelp also lists interactions of Clorazepate with, for example, Calcium / magnesium / potassium / sodium oxybates, Sodium oxybate, Alfentanil. The full list is on the Clorazepate page.
Full monographs, dosing and an interaction checker in the MediHelp app
Open the complete reference, check multi-drug interactions and use dosing tools in the MediHelp app.
