Drug interactions
Clorazepate + Dexmedetomidine
Severity: Moderate
Clorazepate and Dexmedetomidine: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Dexmedetomidine is a sedative and when combined with benzodiazepines the sedative effect is enhanced. Excessive sedation, hypotension and bradycardia may occur.
What this interaction means in plain words
Clorazepate and Dexmedetomidine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Clorazepate belongs to Central Nervous System; Dexmedetomidine belongs to Central Nervous System.
Why it happens
Additive sedation from alpha-2 adrenergic agonism and GABA-A potentiation.
What to do
Titrate dexmedetomidine to sedation score and consider reducing its dose; monitor heart rate, blood pressure and respiration continuously.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Clorazepate
- Calcium / magnesium / potassium / sodium oxybates + Clorazepate Contraindicated
- Clorazepate + Sodium oxybate Contraindicated
- Alfentanil + Clorazepate Major
- Alprazolam + Clorazepate Major
- Amobarbital + Clorazepate Major
- Belladonna and opium + Clorazepate Major
Other interactions of Dexmedetomidine
Frequently asked questions
Can I take Clorazepate with Dexmedetomidine?
MediHelp rates the interaction as moderate. Clorazepate and Dexmedetomidine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Dexmedetomidine is a sedative and when combined with benzodiazepines the sedative effect is enhanced. Excessive sedation, hypotension and bradycardia may occur.
How serious is the interaction between Clorazepate and Dexmedetomidine?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Titrate dexmedetomidine to sedation score and consider reducing its dose; monitor heart rate, blood pressure and respiration continuously.
What other medicines interact with Clorazepate?
MediHelp also lists interactions of Clorazepate with, for example, Calcium / magnesium / potassium / sodium oxybates, Sodium oxybate, Alfentanil. The full list is on the Clorazepate page.
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