Drug interactions
Clorazepate + Etomidate
Severity: Moderate
Clorazepate and Etomidate: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Etomidate is an intravenous anesthetic that acts on GABA-A receptors. Prior clorazepate can enhance sedation and respiratory depression during induction, although the combination is manageable in monitored settings.
What this interaction means in plain words
Clorazepate and Etomidate can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Clorazepate belongs to Central Nervous System; Etomidate belongs to Central Nervous System.
Why it happens
Additive GABA-A mediated CNS depression.
What to do
Titrate etomidate to effect and continuously monitor airway, ventilation and hemodynamics. Inform the anesthesia team of benzodiazepine use.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Clorazepate
- Calcium / magnesium / potassium / sodium oxybates + Clorazepate Contraindicated
- Clorazepate + Sodium oxybate Contraindicated
- Alfentanil + Clorazepate Major
- Alprazolam + Clorazepate Major
- Amobarbital + Clorazepate Major
- Belladonna and opium + Clorazepate Major
Other interactions of Etomidate
- Alprazolam + Etomidate Moderate
- Amitriptyline + Etomidate Moderate
- Amobarbital + Etomidate Moderate
- Azelastine + Etomidate Moderate
- Baclofen + Etomidate Moderate
- Brompheniramine + Etomidate Moderate
Frequently asked questions
Can I take Clorazepate with Etomidate?
MediHelp rates the interaction as moderate. Clorazepate and Etomidate can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Etomidate is an intravenous anesthetic that acts on GABA-A receptors. Prior clorazepate can enhance sedation and respiratory depression during induction, although the combination is manageable in monitored settings.
How serious is the interaction between Clorazepate and Etomidate?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Titrate etomidate to effect and continuously monitor airway, ventilation and hemodynamics. Inform the anesthesia team of benzodiazepine use.
What other medicines interact with Clorazepate?
MediHelp also lists interactions of Clorazepate with, for example, Calcium / magnesium / potassium / sodium oxybates, Sodium oxybate, Alfentanil. The full list is on the Clorazepate page.
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