Drug interactions
Clorazepate + Etravirine
Severity: Moderate
Clorazepate and Etravirine: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Etravirine is a CYP3A4 inducer and may lower exposure to clorazepate's active metabolite. Anxiolytic or anticonvulsant effect could be reduced, although etravirine also inhibits CYP2C9 and CYP2C19, so the net effect is uncertain.
What this interaction means in plain words
Clorazepate and Etravirine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Clorazepate belongs to Central Nervous System; Etravirine belongs to Anti Virals.
Why it happens
Etravirine induces CYP3A4, increasing clearance of clorazepate's active metabolite, with possible offsetting CYP2C19 inhibition.
What to do
Monitor clinical response and adjust the clorazepate dose as needed. Watch for sedation or loss of seizure control when etravirine is started or stopped.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Clorazepate
- Calcium / magnesium / potassium / sodium oxybates + Clorazepate Contraindicated
- Clorazepate + Sodium oxybate Contraindicated
- Alfentanil + Clorazepate Major
- Alprazolam + Clorazepate Major
- Amobarbital + Clorazepate Major
- Belladonna and opium + Clorazepate Major
Other interactions of Etravirine
- Efavirenz + Etravirine Contraindicated
- Etravirine + Isavuconazole Contraindicated
- Amobarbital + Etravirine Major
- Apalutamide + Etravirine Major
- Carbamazepine + Etravirine Major
- Cobicistat + Etravirine Major
Frequently asked questions
Can I take Clorazepate with Etravirine?
MediHelp rates the interaction as moderate. Clorazepate and Etravirine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Etravirine is a CYP3A4 inducer and may lower exposure to clorazepate's active metabolite. Anxiolytic or anticonvulsant effect could be reduced, although etravirine also inhibits CYP2C9 and CYP2C19, so the net effect is uncertain.
How serious is the interaction between Clorazepate and Etravirine?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor clinical response and adjust the clorazepate dose as needed. Watch for sedation or loss of seizure control when etravirine is started or stopped.
What other medicines interact with Clorazepate?
MediHelp also lists interactions of Clorazepate with, for example, Calcium / magnesium / potassium / sodium oxybates, Sodium oxybate, Alfentanil. The full list is on the Clorazepate page.
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