Drug interactions
Clorazepate + Haloperidol
Severity: Moderate
Clorazepate and Haloperidol: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Combined use adds to sedation and psychomotor impairment, and is commonly used deliberately for agitation. Excessive sedation and, uncommonly, respiratory depression can occur, particularly with parenteral dosing or in frail patients.
What this interaction means in plain words
Clorazepate and Haloperidol can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Clorazepate belongs to Central Nervous System; Haloperidol belongs to Central Nervous System.
Why it happens
Additive CNS depression from GABA-A enhancement and dopamine D2 antagonism with sedative properties.
What to do
Monitor level of consciousness, respiration and blood pressure, especially after parenteral doses, and reduce doses in older or debilitated patients.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Clorazepate
- Calcium / magnesium / potassium / sodium oxybates + Clorazepate Contraindicated
- Clorazepate + Sodium oxybate Contraindicated
- Alfentanil + Clorazepate Major
- Alprazolam + Clorazepate Major
- Amobarbital + Clorazepate Major
- Belladonna and opium + Clorazepate Major
Other interactions of Haloperidol
- Dofetilide + Haloperidol Contraindicated
- Dronedarone + Haloperidol Contraindicated
- Haloperidol + Ibutilide Contraindicated
- Haloperidol + Levoketoconazole Contraindicated
- Haloperidol + Panobinostat Contraindicated
- Haloperidol + Pimozide Contraindicated
Frequently asked questions
Can I take Clorazepate with Haloperidol?
MediHelp rates the interaction as moderate. Clorazepate and Haloperidol can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Combined use adds to sedation and psychomotor impairment, and is commonly used deliberately for agitation. Excessive sedation and, uncommonly, respiratory depression can occur, particularly with parenteral dosing or in frail patients.
How serious is the interaction between Clorazepate and Haloperidol?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor level of consciousness, respiration and blood pressure, especially after parenteral doses, and reduce doses in older or debilitated patients.
What other medicines interact with Clorazepate?
MediHelp also lists interactions of Clorazepate with, for example, Calcium / magnesium / potassium / sodium oxybates, Sodium oxybate, Alfentanil. The full list is on the Clorazepate page.
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