Drug interactions
Clorazepate + Letermovir
Severity: Moderate
Clorazepate and Letermovir: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Letermovir inhibits CYP3A4 moderately, which may raise concentrations of clorazepate's active metabolite and increase sedation and psychomotor impairment. The effect is generally dose-dependent and manageable.
What this interaction means in plain words
Clorazepate and Letermovir can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Clorazepate belongs to Central Nervous System; Letermovir belongs to Anti Virals.
Why it happens
Letermovir inhibits CYP3A4, reducing clearance of benzodiazepine substrates.
What to do
Monitor for increased sedation and respiratory depression, and reduce the clorazepate dose if needed. Reassess when letermovir is stopped.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Clorazepate
- Calcium / magnesium / potassium / sodium oxybates + Clorazepate Contraindicated
- Clorazepate + Sodium oxybate Contraindicated
- Alfentanil + Clorazepate Major
- Alprazolam + Clorazepate Major
- Amobarbital + Clorazepate Major
- Belladonna and opium + Clorazepate Major
Other interactions of Letermovir
- Ergotamine + Letermovir Contraindicated
- Letermovir + Pimozide Contraindicated
- Apalutamide + Letermovir Major
- Atorvastatin + Letermovir Major
- Carbamazepine + Letermovir Major
- Colchicine + Letermovir Major
Frequently asked questions
Can I take Clorazepate with Letermovir?
MediHelp rates the interaction as moderate. Clorazepate and Letermovir can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Letermovir inhibits CYP3A4 moderately, which may raise concentrations of clorazepate's active metabolite and increase sedation and psychomotor impairment. The effect is generally dose-dependent and manageable.
How serious is the interaction between Clorazepate and Letermovir?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor for increased sedation and respiratory depression, and reduce the clorazepate dose if needed. Reassess when letermovir is stopped.
What other medicines interact with Clorazepate?
MediHelp also lists interactions of Clorazepate with, for example, Calcium / magnesium / potassium / sodium oxybates, Sodium oxybate, Alfentanil. The full list is on the Clorazepate page.
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