Drug interactions
Clorazepate + Omeprazole
Severity: Minor
Clorazepate and Omeprazole: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Clorazepate is converted to the active metabolite nordiazepam, which is cleared partly by CYP2C19. Omeprazole may modestly increase exposure, causing a little more sedation in some patients. Raised gastric pH may also reduce the acid-dependent conversion of clorazepate to nordiazepam.
What this interaction means in plain words
Clorazepate and Omeprazole have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Clorazepate belongs to Central Nervous System; Omeprazole belongs to Gastrointestinal Tract.
Why it happens
Omeprazole inhibits CYP2C19 and raised gastric pH may alter clorazepate conversion.
What to do
Monitor sedation and clinical response, adjusting the clorazepate dose if needed.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Omeprazole
- Mavacamten + Omeprazole Contraindicated
- Omeprazole + Rilpivirine Contraindicated
- Acalabrutinib + Omeprazole Major
- Atazanavir + Omeprazole Major
- Citalopram + Omeprazole Major
- Clopidogrel + Omeprazole Major
Other interactions of Clorazepate
- Calcium / magnesium / potassium / sodium oxybates + Clorazepate Contraindicated
- Clorazepate + Sodium oxybate Contraindicated
- Alfentanil + Clorazepate Major
- Alprazolam + Clorazepate Major
- Amobarbital + Clorazepate Major
- Belladonna and opium + Clorazepate Major
Frequently asked questions
Can I take Clorazepate with Omeprazole?
MediHelp rates the interaction as minor. Clorazepate and Omeprazole have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Clorazepate is converted to the active metabolite nordiazepam, which is cleared partly by CYP2C19. Omeprazole may modestly increase exposure, causing a little more sedation in some patients. Raised gastric pH may also reduce the acid-dependent conversion of clorazepate to nordiazepam.
How serious is the interaction between Clorazepate and Omeprazole?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor sedation and clinical response, adjusting the clorazepate dose if needed.
What other medicines interact with Omeprazole?
MediHelp also lists interactions of Omeprazole with, for example, Mavacamten, Rilpivirine, Acalabrutinib. The full list is on the Omeprazole page.
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