Drug interactions
Clorazepate + Paliperidone
Severity: Moderate
Clorazepate and Paliperidone: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Both drugs can cause sedation, so combining them may increase drowsiness, dizziness and orthostatic hypotension. The effect is usually manageable but raises the risk of falls.
What this interaction means in plain words
Clorazepate and Paliperidone can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Clorazepate belongs to Central Nervous System; Paliperidone belongs to Central Nervous System.
Why it happens
Additive CNS depression via GABA-A potentiation and paliperidone's antihistaminic and alpha-adrenergic blockade.
What to do
Monitor for sedation and orthostatic changes when starting or increasing either drug. Counsel patients on avoiding driving until tolerance is known.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Clorazepate
- Calcium / magnesium / potassium / sodium oxybates + Clorazepate Contraindicated
- Clorazepate + Sodium oxybate Contraindicated
- Alfentanil + Clorazepate Major
- Alprazolam + Clorazepate Major
- Amobarbital + Clorazepate Major
- Belladonna and opium + Clorazepate Major
Other interactions of Paliperidone
- Ibutilide + Paliperidone Contraindicated
- Paliperidone + Pimozide Contraindicated
- Paliperidone + Vandetanib Contraindicated
- Adagrasib + Paliperidone Major
- Amiodarone + Paliperidone Major
- Amisulpride + Paliperidone Major
Frequently asked questions
Can I take Clorazepate with Paliperidone?
MediHelp rates the interaction as moderate. Clorazepate and Paliperidone can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Both drugs can cause sedation, so combining them may increase drowsiness, dizziness and orthostatic hypotension. The effect is usually manageable but raises the risk of falls.
How serious is the interaction between Clorazepate and Paliperidone?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor for sedation and orthostatic changes when starting or increasing either drug. Counsel patients on avoiding driving until tolerance is known.
What other medicines interact with Clorazepate?
MediHelp also lists interactions of Clorazepate with, for example, Calcium / magnesium / potassium / sodium oxybates, Sodium oxybate, Alfentanil. The full list is on the Clorazepate page.
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