Drug interactions
Clorazepate + Perphenazine
Severity: Moderate
Clorazepate and Perphenazine: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Perphenazine is a sedating phenothiazine antipsychotic, and combining it with a benzodiazepine increases drowsiness, psychomotor impairment and hypotension. Respiratory depression is uncommon but possible at higher doses.
What this interaction means in plain words
Clorazepate and Perphenazine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Clorazepate belongs to Central Nervous System; Perphenazine belongs to Central Nervous System.
Why it happens
Additive CNS depression from GABA-A potentiation and dopamine, histamine and alpha-adrenergic blockade.
What to do
Use the lowest effective doses and monitor sedation and blood pressure. Counsel patients on avoiding alcohol and driving.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Clorazepate
- Calcium / magnesium / potassium / sodium oxybates + Clorazepate Contraindicated
- Clorazepate + Sodium oxybate Contraindicated
- Alfentanil + Clorazepate Major
- Alprazolam + Clorazepate Major
- Amobarbital + Clorazepate Major
- Belladonna and opium + Clorazepate Major
Other interactions of Perphenazine
- Ibutilide + Perphenazine Contraindicated
- Perphenazine + Pimozide Contraindicated
- Perphenazine + Thioridazine Contraindicated
- Adagrasib + Perphenazine Major
- Alfentanil + Perphenazine Major
- Amiodarone + Perphenazine Major
Frequently asked questions
Can I take Clorazepate with Perphenazine?
MediHelp rates the interaction as moderate. Clorazepate and Perphenazine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Perphenazine is a sedating phenothiazine antipsychotic, and combining it with a benzodiazepine increases drowsiness, psychomotor impairment and hypotension. Respiratory depression is uncommon but possible at higher doses.
How serious is the interaction between Clorazepate and Perphenazine?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Use the lowest effective doses and monitor sedation and blood pressure. Counsel patients on avoiding alcohol and driving.
What other medicines interact with Clorazepate?
MediHelp also lists interactions of Clorazepate with, for example, Calcium / magnesium / potassium / sodium oxybates, Sodium oxybate, Alfentanil. The full list is on the Clorazepate page.
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