Drug interactions
Clorazepate + Ribociclib
Severity: Moderate
Clorazepate and Ribociclib: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Ribociclib is a moderate CYP3A4 inhibitor and may raise exposure to CYP3A4-metabolized drugs. Clorazepate is converted to its active metabolite nordazepam, and elevated exposure could increase sedation and psychomotor impairment.
What this interaction means in plain words
Clorazepate and Ribociclib can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Clorazepate belongs to Central Nervous System; Ribociclib belongs to Oncology.
Why it happens
Inhibition of CYP3A4-mediated metabolism by ribociclib, which may increase benzodiazepine exposure.
What to do
Monitor for excess sedation, confusion and respiratory depression, and consider reducing the clorazepate dose. Counsel patients to report excessive drowsiness.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Clorazepate
- Calcium / magnesium / potassium / sodium oxybates + Clorazepate Contraindicated
- Clorazepate + Sodium oxybate Contraindicated
- Alfentanil + Clorazepate Major
- Alprazolam + Clorazepate Major
- Amobarbital + Clorazepate Major
- Belladonna and opium + Clorazepate Major
Other interactions of Ribociclib
- Amiodarone + Ribociclib Contraindicated
- Cisapride + Ribociclib Contraindicated
- Dofetilide + Ribociclib Contraindicated
- Dronedarone + Ribociclib Contraindicated
- Flibanserin + Ribociclib Contraindicated
- Ibutilide + Ribociclib Contraindicated
Frequently asked questions
Can I take Clorazepate with Ribociclib?
MediHelp rates the interaction as moderate. Clorazepate and Ribociclib can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Ribociclib is a moderate CYP3A4 inhibitor and may raise exposure to CYP3A4-metabolized drugs. Clorazepate is converted to its active metabolite nordazepam, and elevated exposure could increase sedation and psychomotor impairment.
How serious is the interaction between Clorazepate and Ribociclib?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor for excess sedation, confusion and respiratory depression, and consider reducing the clorazepate dose. Counsel patients to report excessive drowsiness.
What other medicines interact with Clorazepate?
MediHelp also lists interactions of Clorazepate with, for example, Calcium / magnesium / potassium / sodium oxybates, Sodium oxybate, Alfentanil. The full list is on the Clorazepate page.
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