Drug interactions
Clorazepate + Tazemetostat
Severity: Minor
Clorazepate and Tazemetostat: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Tazemetostat is a weak to moderate CYP3A inducer and may lower exposure to CYP3A substrates such as the active metabolite of clorazepate. This could reduce the benzodiazepine effect.
What this interaction means in plain words
Clorazepate and Tazemetostat have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Clorazepate belongs to Central Nervous System; Tazemetostat belongs to Miscellaneous.
Why it happens
Weak induction of CYP3A4 by tazemetostat increases metabolism of clorazepate's active metabolite.
What to do
Monitor for reduced anxiolytic or anticonvulsant effect and adjust the clorazepate dose if needed.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Clorazepate
- Calcium / magnesium / potassium / sodium oxybates + Clorazepate Contraindicated
- Clorazepate + Sodium oxybate Contraindicated
- Alfentanil + Clorazepate Major
- Alprazolam + Clorazepate Major
- Amobarbital + Clorazepate Major
- Belladonna and opium + Clorazepate Major
Other interactions of Tazemetostat
Frequently asked questions
Can I take Clorazepate with Tazemetostat?
MediHelp rates the interaction as minor. Clorazepate and Tazemetostat have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Tazemetostat is a weak to moderate CYP3A inducer and may lower exposure to CYP3A substrates such as the active metabolite of clorazepate. This could reduce the benzodiazepine effect.
How serious is the interaction between Clorazepate and Tazemetostat?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor for reduced anxiolytic or anticonvulsant effect and adjust the clorazepate dose if needed.
What other medicines interact with Clorazepate?
MediHelp also lists interactions of Clorazepate with, for example, Calcium / magnesium / potassium / sodium oxybates, Sodium oxybate, Alfentanil. The full list is on the Clorazepate page.
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