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Drug interactions

Clorazepate + Teduglutide

Severity: Minor

Clorazepate and Teduglutide: minor interaction.

Last updated

For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.

Summary

Teduglutide improves intestinal fluid and nutrient absorption and may increase absorption of oral drugs. For clorazepate this could mean higher exposure and more sedation, though data specific to this drug are lacking.

What this interaction means in plain words

Clorazepate and Teduglutide have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.

Clorazepate belongs to Central Nervous System; Teduglutide belongs to Endocrine.

Evidence level: Low

Why it happens

Increased intestinal absorption of oral drugs due to the intestinotrophic effect of teduglutide.

What to do

Monitor for increased sedation after teduglutide is started and reduce the clorazepate dose if needed.

What to ask your pharmacist

  • Is there anything I should notice while taking both?
  • Do I need to tell my doctor at the next visit?

Bring a full list of your medicines, including over-the-counter products, supplements and herbal remedies, to every pharmacy visit.

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Frequently asked questions

Can I take Clorazepate with Teduglutide?

MediHelp rates the interaction as minor. Clorazepate and Teduglutide have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Teduglutide improves intestinal fluid and nutrient absorption and may increase absorption of oral drugs. For clorazepate this could mean higher exposure and more sedation, though data specific to this drug are lacking.

How serious is the interaction between Clorazepate and Teduglutide?

MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor for increased sedation after teduglutide is started and reduce the clorazepate dose if needed.

What other medicines interact with Clorazepate?

MediHelp also lists interactions of Clorazepate with, for example, Calcium / magnesium / potassium / sodium oxybates, Sodium oxybate, Alfentanil. The full list is on the Clorazepate page.

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