Drug interactions
Clorazepate + Temazepam
Severity: Moderate
Clorazepate and Temazepam: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Using two benzodiazepines together causes additive sedation, psychomotor impairment and respiratory depression, with little added benefit. Falls and next-day impairment become more likely.
What this interaction means in plain words
Clorazepate and Temazepam can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Clorazepate belongs to Central Nervous System; Temazepam belongs to Central Nervous System.
Why it happens
Additive GABA-A receptor potentiation.
What to do
Avoid duplicate benzodiazepine therapy where possible and consolidate to one agent. If both are required, use the lowest doses and monitor for oversedation.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Clorazepate
- Calcium / magnesium / potassium / sodium oxybates + Clorazepate Contraindicated
- Clorazepate + Sodium oxybate Contraindicated
- Alfentanil + Clorazepate Major
- Alprazolam + Clorazepate Major
- Amobarbital + Clorazepate Major
- Belladonna and opium + Clorazepate Major
Other interactions of Temazepam
- Alprazolam + Temazepam Major
- Amobarbital + Temazepam Major
- Buprenorphine + Temazepam Major
- Butorphanol + Temazepam Major
- Carisoprodol + Temazepam Major
- Chloral hydrate + Temazepam Major
Frequently asked questions
Can I take Clorazepate with Temazepam?
MediHelp rates the interaction as moderate. Clorazepate and Temazepam can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Using two benzodiazepines together causes additive sedation, psychomotor impairment and respiratory depression, with little added benefit. Falls and next-day impairment become more likely.
How serious is the interaction between Clorazepate and Temazepam?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid duplicate benzodiazepine therapy where possible and consolidate to one agent. If both are required, use the lowest doses and monitor for oversedation.
What other medicines interact with Clorazepate?
MediHelp also lists interactions of Clorazepate with, for example, Calcium / magnesium / potassium / sodium oxybates, Sodium oxybate, Alfentanil. The full list is on the Clorazepate page.
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