Drug interactions
Clorazepate + Tipranavir
Severity: Moderate
Clorazepate and Tipranavir: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Ritonavir-boosted tipranavir has mixed CYP3A4 effects, but net inhibition is expected to raise levels of clorazepate's active metabolite. Sedation and respiratory depression may be enhanced.
What this interaction means in plain words
Clorazepate and Tipranavir can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Clorazepate belongs to Central Nervous System; Tipranavir belongs to Anti Virals.
Why it happens
Net inhibition of CYP3A4 by the ritonavir-boosted regimen reduces benzodiazepine clearance.
What to do
Monitor for excessive sedation and reduce the clorazepate dose if needed, or use lorazepam instead.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Clorazepate
- Calcium / magnesium / potassium / sodium oxybates + Clorazepate Contraindicated
- Clorazepate + Sodium oxybate Contraindicated
- Alfentanil + Clorazepate Major
- Alprazolam + Clorazepate Major
- Amobarbital + Clorazepate Major
- Belladonna and opium + Clorazepate Major
Other interactions of Tipranavir
- Alfuzosin + Tipranavir Contraindicated
- Amiodarone + Tipranavir Contraindicated
- Atorvastatin + Tipranavir Contraindicated
- Avanafil + Tipranavir Contraindicated
- Cisapride + Tipranavir Contraindicated
- Colchicine + Tipranavir Contraindicated
Frequently asked questions
Can I take Clorazepate with Tipranavir?
MediHelp rates the interaction as moderate. Clorazepate and Tipranavir can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Ritonavir-boosted tipranavir has mixed CYP3A4 effects, but net inhibition is expected to raise levels of clorazepate's active metabolite. Sedation and respiratory depression may be enhanced.
How serious is the interaction between Clorazepate and Tipranavir?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor for excessive sedation and reduce the clorazepate dose if needed, or use lorazepam instead.
What other medicines interact with Clorazepate?
MediHelp also lists interactions of Clorazepate with, for example, Calcium / magnesium / potassium / sodium oxybates, Sodium oxybate, Alfentanil. The full list is on the Clorazepate page.
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