Drug interactions
Clotrimazole + Gepirone
Severity: Moderate
Clotrimazole and Gepirone: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Systemically absorbed clotrimazole may inhibit CYP3A4 and increase gepirone exposure. This can increase dizziness, sedation, QT prolongation and other adverse effects of gepirone.
What this interaction means in plain words
Clotrimazole and Gepirone can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Clotrimazole belongs to Anti Fungals; Gepirone belongs to Central Nervous System.
Why it happens
Inhibition of CYP3A4-mediated metabolism of gepirone.
What to do
Reduce gepirone dose as per labeling for moderate CYP3A4 inhibitors and monitor for adverse effects including QT prolongation. Return to the usual dose after the inhibitor is stopped.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Clotrimazole
- Clotrimazole + Lomitapide Major
- Clotrimazole + Mavacamten Major
- Clotrimazole + Mobocertinib Major
- Clotrimazole + Voclosporin Major
- Bosutinib + Clotrimazole Moderate
- Cannabidiol + Clotrimazole Moderate
Other interactions of Gepirone
- Clarithromycin + Gepirone Contraindicated
- Gepirone + Isocarboxazid Contraindicated
- Gepirone + Itraconazole Contraindicated
- Gepirone + Ketoconazole Contraindicated
- Gepirone + Linezolid Contraindicated
- Gepirone + Phenelzine Contraindicated
Frequently asked questions
Can I take Clotrimazole with Gepirone?
MediHelp rates the interaction as moderate. Clotrimazole and Gepirone can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Systemically absorbed clotrimazole may inhibit CYP3A4 and increase gepirone exposure. This can increase dizziness, sedation, QT prolongation and other adverse effects of gepirone.
How serious is the interaction between Clotrimazole and Gepirone?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Reduce gepirone dose as per labeling for moderate CYP3A4 inhibitors and monitor for adverse effects including QT prolongation. Return to the usual dose after the inhibitor is stopped.
What other medicines interact with Clotrimazole?
MediHelp also lists interactions of Clotrimazole with, for example, Lomitapide, Mavacamten, Mobocertinib. The full list is on the Clotrimazole page.
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