Drug interactions
Clotrimazole + Levamlodipine
Severity: Minor
Clotrimazole and Levamlodipine: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Systemic clotrimazole may inhibit CYP3A4 and raise levamlodipine concentrations. This may cause more hypotension and peripheral edema.
What this interaction means in plain words
Clotrimazole and Levamlodipine have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Clotrimazole belongs to Anti Fungals; Levamlodipine belongs to Cardiovascular.
Why it happens
Inhibition of CYP3A4-mediated metabolism of levamlodipine.
What to do
Monitor blood pressure and edema when clotrimazole is used systemically. Reduce the levamlodipine dose if symptomatic hypotension or edema develops.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Clotrimazole
- Clotrimazole + Lomitapide Major
- Clotrimazole + Mavacamten Major
- Clotrimazole + Mobocertinib Major
- Clotrimazole + Voclosporin Major
- Bosutinib + Clotrimazole Moderate
- Cannabidiol + Clotrimazole Moderate
Other interactions of Levamlodipine
- Dantrolene + Levamlodipine Major
- Amiodarone + Levamlodipine Moderate
- Amobarbital + Levamlodipine Moderate
- Apalutamide + Levamlodipine Moderate
- Aprepitant + Levamlodipine Moderate
- Armodafinil + Levamlodipine Moderate
Frequently asked questions
Can I take Clotrimazole with Levamlodipine?
MediHelp rates the interaction as minor. Clotrimazole and Levamlodipine have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Systemic clotrimazole may inhibit CYP3A4 and raise levamlodipine concentrations. This may cause more hypotension and peripheral edema.
How serious is the interaction between Clotrimazole and Levamlodipine?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor blood pressure and edema when clotrimazole is used systemically. Reduce the levamlodipine dose if symptomatic hypotension or edema develops.
What other medicines interact with Clotrimazole?
MediHelp also lists interactions of Clotrimazole with, for example, Lomitapide, Mavacamten, Mobocertinib. The full list is on the Clotrimazole page.
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