Drug interactions
Clozapine + Lisdexamfetamine
Severity: Moderate
Clozapine and Lisdexamfetamine: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Clozapine is sedating and can cause tachycardia, hypotension and myocarditis, while amphetamines are stimulants that raise heart rate and blood pressure. The effects oppose each other in the CNS and may complicate cardiovascular monitoring.
What this interaction means in plain words
Clozapine and Lisdexamfetamine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Clozapine belongs to Central Nervous System; Lisdexamfetamine belongs to Central Nervous System.
Why it happens
Opposing CNS effects and overlapping cardiovascular effects of a stimulant and an atypical antipsychotic.
What to do
Monitor heart rate, blood pressure and psychotic symptoms, as stimulants may worsen psychosis. Reassess the need for the stimulant if psychiatric symptoms or tachycardia worsen.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Lisdexamfetamine
- Isocarboxazid + Lisdexamfetamine Contraindicated
- Linezolid + Lisdexamfetamine Contraindicated
- Lisdexamfetamine + Phenelzine Contraindicated
- Lisdexamfetamine + Procarbazine Contraindicated
- Lisdexamfetamine + Rasagiline Contraindicated
- Lisdexamfetamine + Safinamide Contraindicated
Other interactions of Clozapine
- Clozapine + Deferiprone Contraindicated
- Clozapine + Irinotecan Contraindicated
- Clozapine + Pimozide Contraindicated
- Clozapine + Thioridazine Contraindicated
- Acalabrutinib + Clozapine Major
- Adagrasib + Clozapine Major
Frequently asked questions
Can I take Clozapine with Lisdexamfetamine?
MediHelp rates the interaction as moderate. Clozapine and Lisdexamfetamine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Clozapine is sedating and can cause tachycardia, hypotension and myocarditis, while amphetamines are stimulants that raise heart rate and blood pressure. The effects oppose each other in the CNS and may complicate cardiovascular monitoring.
How serious is the interaction between Clozapine and Lisdexamfetamine?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor heart rate, blood pressure and psychotic symptoms, as stimulants may worsen psychosis. Reassess the need for the stimulant if psychiatric symptoms or tachycardia worsen.
What other medicines interact with Lisdexamfetamine?
MediHelp also lists interactions of Lisdexamfetamine with, for example, Isocarboxazid, Linezolid, Phenelzine. The full list is on the Lisdexamfetamine page.
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