Drug interactions
Clozapine + Prochlorperazine
Severity: Major
Clozapine and Prochlorperazine: major interaction.
Last updated Sources: US FDA label
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Both are antipsychotics with strong sedative effects. The combination increases the risk of extrapyramidal symptoms, neuroleptic malignant syndrome, hypotension, QT prolongation and seizures, and clozapine adds agranulocytosis and myocarditis risk.
What this interaction means in plain words
Clozapine and Prochlorperazine can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Clozapine belongs to Central Nervous System; Prochlorperazine belongs to Central Nervous System.
Why it happens
Additive dopamine D2 blockade, CNS depression, hypotension and QT effects.
What to do
Avoid routine combination of antipsychotics with clozapine where possible; if used, monitor ECG, blood pressure, sedation and movement disorders. Watch for fever, rigidity and altered consciousness.
What to ask your pharmacist
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
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References
Other interactions of Prochlorperazine
- Dronedarone + Prochlorperazine Contraindicated
- Ibutilide + Prochlorperazine Contraindicated
- Nilotinib + Prochlorperazine Contraindicated
- Pimozide + Prochlorperazine Contraindicated
- Prochlorperazine + Thioridazine Contraindicated
- Amiodarone + Prochlorperazine Major
Other interactions of Clozapine
- Clozapine + Deferiprone Contraindicated
- Clozapine + Irinotecan Contraindicated
- Clozapine + Pimozide Contraindicated
- Clozapine + Thioridazine Contraindicated
- Acalabrutinib + Clozapine Major
- Adagrasib + Clozapine Major
Frequently asked questions
Can I take Clozapine with Prochlorperazine?
MediHelp rates the interaction as major. Clozapine and Prochlorperazine can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Both are antipsychotics with strong sedative effects. The combination increases the risk of extrapyramidal symptoms, neuroleptic malignant syndrome, hypotension, QT prolongation and seizures, and clozapine adds agranulocytosis and myocarditis risk.
How serious is the interaction between Clozapine and Prochlorperazine?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid routine combination of antipsychotics with clozapine where possible; if used, monitor ECG, blood pressure, sedation and movement disorders. Watch for fever, rigidity and altered consciousness.
What other medicines interact with Prochlorperazine?
MediHelp also lists interactions of Prochlorperazine with, for example, Dronedarone, Ibutilide, Nilotinib. The full list is on the Prochlorperazine page.
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