Drug interactions
Clozapine + Vilazodone
Severity: Moderate
Clozapine and Vilazodone: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Both drugs act on serotonergic pathways, and clozapine is a potent dopamine and serotonin receptor antagonist. Combined use may rarely cause serotonin syndrome or neuroleptic malignant syndrome.
What this interaction means in plain words
Clozapine and Vilazodone can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Clozapine belongs to Central Nervous System; Vilazodone belongs to Central Nervous System.
Why it happens
Additive serotonergic effects together with dopamine and serotonin receptor blockade, a pharmacodynamic interaction.
What to do
Monitor for mental status change, myoclonus, fever, rigidity and autonomic instability, particularly during dose changes. Stop the combination and treat supportively if toxicity is suspected.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Vilazodone
- Isocarboxazid + Vilazodone Contraindicated
- Methylene blue + Vilazodone Contraindicated
- Phenelzine + Vilazodone Contraindicated
- Rasagiline + Vilazodone Contraindicated
- Selegiline transdermal + Vilazodone Contraindicated
- Selegiline + Vilazodone Contraindicated
Other interactions of Clozapine
- Clozapine + Deferiprone Contraindicated
- Clozapine + Irinotecan Contraindicated
- Clozapine + Pimozide Contraindicated
- Clozapine + Thioridazine Contraindicated
- Acalabrutinib + Clozapine Major
- Adagrasib + Clozapine Major
Frequently asked questions
Can I take Clozapine with Vilazodone?
MediHelp rates the interaction as moderate. Clozapine and Vilazodone can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Both drugs act on serotonergic pathways, and clozapine is a potent dopamine and serotonin receptor antagonist. Combined use may rarely cause serotonin syndrome or neuroleptic malignant syndrome.
How serious is the interaction between Clozapine and Vilazodone?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor for mental status change, myoclonus, fever, rigidity and autonomic instability, particularly during dose changes. Stop the combination and treat supportively if toxicity is suspected.
What other medicines interact with Vilazodone?
MediHelp also lists interactions of Vilazodone with, for example, Isocarboxazid, Methylene blue, Phenelzine. The full list is on the Vilazodone page.
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