Drug interactions
Cobicistat + Modafinil
Severity: Moderate
Cobicistat and Modafinil: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Cobicistat is a strong CYP3A inhibitor and may raise modafinil concentrations, increasing adverse effects such as anxiety, insomnia, headache and increased blood pressure. The effect is expected to be modest.
What this interaction means in plain words
Cobicistat and Modafinil can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Cobicistat belongs to Miscellaneous; Modafinil belongs to Central Nervous System.
Why it happens
Cobicistat inhibits CYP3A4-mediated metabolism of modafinil.
What to do
Monitor for modafinil adverse effects and blood pressure, and reduce the modafinil dose if they occur.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Modafinil
Other interactions of Cobicistat
- Alfuzosin + Cobicistat Contraindicated
- Apalutamide + Cobicistat Contraindicated
- Cobicistat + Colchicine Contraindicated
- Cobicistat + Dronedarone Contraindicated
- Cobicistat + Eletriptan Contraindicated
- Cobicistat + Eplerenone Contraindicated
Frequently asked questions
Can I take Cobicistat with Modafinil?
MediHelp rates the interaction as moderate. Cobicistat and Modafinil can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Cobicistat is a strong CYP3A inhibitor and may raise modafinil concentrations, increasing adverse effects such as anxiety, insomnia, headache and increased blood pressure. The effect is expected to be modest.
How serious is the interaction between Cobicistat and Modafinil?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor for modafinil adverse effects and blood pressure, and reduce the modafinil dose if they occur.
What other medicines interact with Modafinil?
MediHelp also lists interactions of Modafinil with, for example, Lenacapavir, Leniolisib, Lorlatinib. The full list is on the Modafinil page.
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