Drug interactions
Cobicistat + Risperidone
Severity: Moderate
Cobicistat and Risperidone: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Cobicistat inhibits CYP3A4 and CYP2D6, the main enzymes clearing risperidone, and may raise levels of risperidone and its active metabolite. This can increase sedation, extrapyramidal symptoms, hypotension and QT effects.
What this interaction means in plain words
Cobicistat and Risperidone can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Cobicistat belongs to Miscellaneous; Risperidone belongs to Central Nervous System.
Why it happens
Inhibition of CYP2D6 and CYP3A4 reduces risperidone metabolism.
What to do
Consider a lower risperidone dose when starting cobicistat and monitor for extrapyramidal symptoms and sedation. Titrate according to clinical response.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Risperidone
- Ibutilide + Risperidone Contraindicated
- Risperidone + Vandetanib Contraindicated
- Adagrasib + Risperidone Major
- Amiodarone + Risperidone Major
- Amisulpride + Risperidone Major
- Amoxapine + Risperidone Major
Other interactions of Cobicistat
- Alfuzosin + Cobicistat Contraindicated
- Apalutamide + Cobicistat Contraindicated
- Cobicistat + Colchicine Contraindicated
- Cobicistat + Dronedarone Contraindicated
- Cobicistat + Eletriptan Contraindicated
- Cobicistat + Eplerenone Contraindicated
Frequently asked questions
Can I take Cobicistat with Risperidone?
MediHelp rates the interaction as moderate. Cobicistat and Risperidone can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Cobicistat inhibits CYP3A4 and CYP2D6, the main enzymes clearing risperidone, and may raise levels of risperidone and its active metabolite. This can increase sedation, extrapyramidal symptoms, hypotension and QT effects.
How serious is the interaction between Cobicistat and Risperidone?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Consider a lower risperidone dose when starting cobicistat and monitor for extrapyramidal symptoms and sedation. Titrate according to clinical response.
What other medicines interact with Risperidone?
MediHelp also lists interactions of Risperidone with, for example, Ibutilide, Vandetanib, Adagrasib. The full list is on the Risperidone page.
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