Drug interactions
Codeine + Perampanel
Severity: Moderate
Codeine and Perampanel: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Perampanel causes dizziness, somnolence and impaired psychomotor function, and combining it with codeine adds to CNS depression. This raises the risk of sedation, falls and impaired alertness, and opioid-related respiratory depression is a concern at higher doses.
What this interaction means in plain words
Codeine and Perampanel can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Codeine belongs to Musculoskeletal; Perampanel belongs to Central Nervous System.
Why it happens
Additive CNS depressant effects.
What to do
Use the lowest effective codeine dose and counsel the patient about sedation and driving. Monitor for excessive drowsiness and respiratory depression, especially during initiation or dose increases.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Codeine
- Alvimopan + Codeine Contraindicated
- Codeine + Isocarboxazid Contraindicated
- Codeine + Olanzapine / samidorphan Contraindicated
- Codeine + Phenelzine Contraindicated
- Codeine + Tranylcypromine Contraindicated
- Alfentanil + Codeine Major
Other interactions of Perampanel
- Apalutamide + Perampanel Major
- Enzalutamide + Perampanel Major
- Alprazolam + Perampanel Moderate
- Amisulpride + Perampanel Moderate
- Amobarbital + Perampanel Moderate
- Asenapine + Perampanel Moderate
Frequently asked questions
Can I take Codeine with Perampanel?
MediHelp rates the interaction as moderate. Codeine and Perampanel can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Perampanel causes dizziness, somnolence and impaired psychomotor function, and combining it with codeine adds to CNS depression. This raises the risk of sedation, falls and impaired alertness, and opioid-related respiratory depression is a concern at higher doses.
How serious is the interaction between Codeine and Perampanel?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Use the lowest effective codeine dose and counsel the patient about sedation and driving. Monitor for excessive drowsiness and respiratory depression, especially during initiation or dose increases.
What other medicines interact with Codeine?
MediHelp also lists interactions of Codeine with, for example, Alvimopan, Isocarboxazid, Olanzapine / samidorphan. The full list is on the Codeine page.
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