Drug interactions
Codeine + Ticlopidine
Severity: Moderate
Codeine and Ticlopidine: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Ticlopidine inhibits CYP2D6 and may reduce the formation of morphine from codeine, potentially weakening analgesia. The extent in individual patients is variable.
What this interaction means in plain words
Codeine and Ticlopidine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Codeine belongs to Musculoskeletal; Ticlopidine belongs to Cardiovascular.
Why it happens
Ticlopidine inhibits CYP2D6-mediated conversion of codeine to morphine.
What to do
Monitor pain relief and consider an analgesic not reliant on CYP2D6, such as morphine, if the response is poor. Avoid escalating codeine doses.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
Pro+ members
Unlock the full page
Create an account and start a Pro+ trial to unlock the full management advice for Codeine and Ticlopidine, the additional notes, the evidence detail and the whole-prescription interaction checker.
- Full clinical management advice
- Additional notes
- Evidence detail
- Interaction checker for a whole prescription
Try Pro+ free for 7 days on the web. No card needed.
Other interactions of Codeine
- Alvimopan + Codeine Contraindicated
- Codeine + Isocarboxazid Contraindicated
- Codeine + Olanzapine / samidorphan Contraindicated
- Codeine + Phenelzine Contraindicated
- Codeine + Tranylcypromine Contraindicated
- Alfentanil + Codeine Major
Other interactions of Ticlopidine
Frequently asked questions
Can I take Codeine with Ticlopidine?
MediHelp rates the interaction as moderate. Codeine and Ticlopidine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Ticlopidine inhibits CYP2D6 and may reduce the formation of morphine from codeine, potentially weakening analgesia. The extent in individual patients is variable.
How serious is the interaction between Codeine and Ticlopidine?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor pain relief and consider an analgesic not reliant on CYP2D6, such as morphine, if the response is poor. Avoid escalating codeine doses.
What other medicines interact with Codeine?
MediHelp also lists interactions of Codeine with, for example, Alvimopan, Isocarboxazid, Olanzapine / samidorphan. The full list is on the Codeine page.
Full monographs, dosing and an interaction checker in the MediHelp app
Open the complete reference, check multi-drug interactions and use dosing tools in the MediHelp app.
