Drug interactions
Colchicine + Elacestrant
Severity: Moderate
Colchicine and Elacestrant: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Elacestrant inhibits P-glycoprotein and may raise colchicine concentrations. Since colchicine has a narrow therapeutic window, higher exposure can lead to gastrointestinal, neuromuscular and bone marrow toxicity.
What this interaction means in plain words
Colchicine and Elacestrant can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Colchicine belongs to Genitourinary; Elacestrant belongs to Oncology.
Why it happens
P-glycoprotein inhibition by elacestrant reduces colchicine efflux and clearance.
What to do
Consider reducing the colchicine dose and monitor for diarrhea, myalgia, weakness and cytopenias. Avoid the combination in significant renal or hepatic impairment.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Colchicine
- Clarithromycin + Colchicine Contraindicated
- Cobicistat + Colchicine Contraindicated
- Colchicine + Cyclosporine Contraindicated
- Colchicine + Ensitrelvir Contraindicated
- Colchicine + Levoketoconazole Contraindicated
- Colchicine + Nirmatrelvir Contraindicated
Other interactions of Elacestrant
Frequently asked questions
Can I take Colchicine with Elacestrant?
MediHelp rates the interaction as moderate. Colchicine and Elacestrant can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Elacestrant inhibits P-glycoprotein and may raise colchicine concentrations. Since colchicine has a narrow therapeutic window, higher exposure can lead to gastrointestinal, neuromuscular and bone marrow toxicity.
How serious is the interaction between Colchicine and Elacestrant?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Consider reducing the colchicine dose and monitor for diarrhea, myalgia, weakness and cytopenias. Avoid the combination in significant renal or hepatic impairment.
What other medicines interact with Colchicine?
MediHelp also lists interactions of Colchicine with, for example, Clarithromycin, Cobicistat, Cyclosporine. The full list is on the Colchicine page.
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