Drug interactions
Colchicine + Lenacapavir
Severity: Major
Colchicine and Lenacapavir: major interaction.
Last updated Sources: US FDA label
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Lenacapavir is a moderate CYP3A inhibitor and also inhibits P-gp, so it may increase colchicine exposure and the risk of toxicity. The effect may persist for months after subcutaneous dosing because of its long half-life.
What this interaction means in plain words
Colchicine and Lenacapavir can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Colchicine belongs to Genitourinary; Lenacapavir belongs to Anti Virals.
Why it happens
Lenacapavir inhibits CYP3A4 and P-glycoprotein, decreasing colchicine clearance.
What to do
Reduce the colchicine dose per labeling for moderate CYP3A4 inhibitors and monitor for toxicity. Avoid in patients with renal or hepatic impairment.
What to ask your pharmacist
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
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References
Other interactions of Colchicine
- Clarithromycin + Colchicine Contraindicated
- Cobicistat + Colchicine Contraindicated
- Colchicine + Cyclosporine Contraindicated
- Colchicine + Ensitrelvir Contraindicated
- Colchicine + Levoketoconazole Contraindicated
- Colchicine + Nirmatrelvir Contraindicated
Other interactions of Lenacapavir
- Apalutamide + Lenacapavir Contraindicated
- Carbamazepine + Lenacapavir Contraindicated
- Enzalutamide + Lenacapavir Contraindicated
- Flibanserin + Lenacapavir Contraindicated
- Lenacapavir + Phenytoin Contraindicated
- Lenacapavir + Rifampicin Contraindicated
Frequently asked questions
Can I take Colchicine with Lenacapavir?
MediHelp rates the interaction as major. Colchicine and Lenacapavir can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Lenacapavir is a moderate CYP3A inhibitor and also inhibits P-gp, so it may increase colchicine exposure and the risk of toxicity. The effect may persist for months after subcutaneous dosing because of its long half-life.
How serious is the interaction between Colchicine and Lenacapavir?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Reduce the colchicine dose per labeling for moderate CYP3A4 inhibitors and monitor for toxicity. Avoid in patients with renal or hepatic impairment.
What other medicines interact with Colchicine?
MediHelp also lists interactions of Colchicine with, for example, Clarithromycin, Cobicistat, Cyclosporine. The full list is on the Colchicine page.
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