Drug interactions
Colchicine + Ustekinumab
Severity: Minor
Colchicine and Ustekinumab: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Ustekinumab may normalize CYP3A activity suppressed by inflammation, potentially lowering colchicine exposure. Colchicine has a narrow therapeutic index, so changes could matter, though this is theoretical.
What this interaction means in plain words
Colchicine and Ustekinumab have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Colchicine belongs to Genitourinary; Ustekinumab belongs to Gastrointestinal Tract.
Why it happens
Cytokine modulation may restore CYP3A4 expression, altering colchicine metabolism.
What to do
Monitor colchicine efficacy and for toxicity such as gastrointestinal effects or myopathy when ustekinumab is started or stopped.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Ustekinumab
- Bcg vaccine live + Ustekinumab Contraindicated
- Typhoid vaccine live + Ustekinumab Contraindicated
- Adalimumab + Ustekinumab Major
- Adenovirus types 4 and 7 live + Ustekinumab Major
- Alefacept + Ustekinumab Major
- Anakinra + Ustekinumab Major
Other interactions of Colchicine
- Clarithromycin + Colchicine Contraindicated
- Cobicistat + Colchicine Contraindicated
- Colchicine + Cyclosporine Contraindicated
- Colchicine + Ensitrelvir Contraindicated
- Colchicine + Levoketoconazole Contraindicated
- Colchicine + Nirmatrelvir Contraindicated
Frequently asked questions
Can I take Colchicine with Ustekinumab?
MediHelp rates the interaction as minor. Colchicine and Ustekinumab have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Ustekinumab may normalize CYP3A activity suppressed by inflammation, potentially lowering colchicine exposure. Colchicine has a narrow therapeutic index, so changes could matter, though this is theoretical.
How serious is the interaction between Colchicine and Ustekinumab?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor colchicine efficacy and for toxicity such as gastrointestinal effects or myopathy when ustekinumab is started or stopped.
What other medicines interact with Ustekinumab?
MediHelp also lists interactions of Ustekinumab with, for example, Bcg vaccine live, Typhoid vaccine live, Adalimumab. The full list is on the Ustekinumab page.
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