Drug interactions
colchicine + verapamil
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Overview
↑ colchicine exposure → neuromyopathy risk.
Mechanism of action
P-gp/CYP3A4 inhibition.
Clinical management
Avoid or reduce colchicine dose; monitor toxicity.
Drug reference
References
Frequently asked questions
Can I take colchicine with verapamil?
The interaction is rated: Major. ↑ colchicine exposure → neuromyopathy risk.
How serious is the interaction between colchicine and verapamil?
The interaction is rated: Major. Evidence level: High.
How is the interaction between colchicine and verapamil managed?
Avoid or reduce colchicine dose; monitor toxicity.
Why do colchicine and verapamil interact?
P-gp/CYP3A4 inhibition.
Full monographs, dosing and an interaction checker in the MediHelp app
Open the complete reference, check multi-drug interactions and use dosing tools in the MediHelp app.