Drug interactions
Colchicine + Voclosporin
Severity: Major
Colchicine and Voclosporin: major interaction.
Last updated Sources: US FDA label
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Voclosporin inhibits P-glycoprotein and CYP3A4, and may increase colchicine exposure. Colchicine toxicity, including myopathy and cytopenias, becomes more likely, especially with renal impairment, which is common in lupus nephritis.
What this interaction means in plain words
Colchicine and Voclosporin can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Colchicine belongs to Genitourinary; Voclosporin belongs to Miscellaneous.
Why it happens
Voclosporin inhibits P-glycoprotein efflux and CYP3A4, reducing colchicine elimination.
What to do
Reduce the colchicine dose per labeling and monitor for diarrhea, myopathy and blood count changes. Avoid the combination if renal or hepatic function is significantly impaired.
What to ask your pharmacist
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
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References
Other interactions of Colchicine
- Clarithromycin + Colchicine Contraindicated
- Cobicistat + Colchicine Contraindicated
- Colchicine + Cyclosporine Contraindicated
- Colchicine + Ensitrelvir Contraindicated
- Colchicine + Levoketoconazole Contraindicated
- Colchicine + Nirmatrelvir Contraindicated
Other interactions of Voclosporin
- Clarithromycin + Voclosporin Contraindicated
- Cyclosporin + Voclosporin Contraindicated
- Ensitrelvir + Voclosporin Contraindicated
- Itraconazole + Voclosporin Contraindicated
- Ketoconazole + Voclosporin Contraindicated
- Posaconazole + Voclosporin Contraindicated
Frequently asked questions
Can I take Colchicine with Voclosporin?
MediHelp rates the interaction as major. Colchicine and Voclosporin can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Voclosporin inhibits P-glycoprotein and CYP3A4, and may increase colchicine exposure. Colchicine toxicity, including myopathy and cytopenias, becomes more likely, especially with renal impairment, which is common in lupus nephritis.
How serious is the interaction between Colchicine and Voclosporin?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Reduce the colchicine dose per labeling and monitor for diarrhea, myopathy and blood count changes. Avoid the combination if renal or hepatic function is significantly impaired.
What other medicines interact with Colchicine?
MediHelp also lists interactions of Colchicine with, for example, Clarithromycin, Cobicistat, Cyclosporine. The full list is on the Colchicine page.
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