Drug interactions
Colesevelam + Empagliflozin-metformin
Severity: Minor
Colesevelam and Empagliflozin-metformin: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Colesevelam lowers blood glucose modestly and is used as an adjunct in type 2 diabetes. Bile acid sequestrants may also bind metformin in the gut and slightly reduce its absorption, though the effect is of limited importance.
What this interaction means in plain words
Colesevelam and Empagliflozin-metformin have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Colesevelam belongs to Endocrine; Empagliflozin-metformin belongs to Endocrine.
Why it happens
Possible binding of metformin in the gastrointestinal tract by the bile acid sequestrant, combined with additive glucose-lowering effects.
What to do
Monitor glucose when starting or stopping colesevelam; if concerned, give metformin at least 4 hours before colesevelam.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Empagliflozin-metformin
Other interactions of Colesevelam
- Amlodipine-olmesartan-hydrochlorothiazide + Colesevelam Moderate
- Amlodipine-olmesartan + Colesevelam Moderate
- Chenodiol + Colesevelam Moderate
- Cholic acid + Colesevelam Moderate
- Colesevelam + Cyclosporin Moderate
- Colesevelam + Glibenclamide Moderate
Frequently asked questions
Can I take Colesevelam with Empagliflozin-metformin?
MediHelp rates the interaction as minor. Colesevelam and Empagliflozin-metformin have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Colesevelam lowers blood glucose modestly and is used as an adjunct in type 2 diabetes. Bile acid sequestrants may also bind metformin in the gut and slightly reduce its absorption, though the effect is of limited importance.
How serious is the interaction between Colesevelam and Empagliflozin-metformin?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor glucose when starting or stopping colesevelam; if concerned, give metformin at least 4 hours before colesevelam.
What other medicines interact with Empagliflozin-metformin?
MediHelp also lists interactions of Empagliflozin-metformin with, for example, Contrast media, Diatrizoate meglumine / diatrizoate, Diatrizoate. The full list is on the Empagliflozin-metformin page.
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