Drug interactions
Colesevelam + Glipizide-metformin
Severity: Moderate
Colesevelam and Glipizide-metformin: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Colesevelam can bind glipizide in the gut and lower its absorption when taken together. Colesevelam also lowers glucose and may add to the effect of the antidiabetic drugs, and it can reduce metformin ER absorption.
What this interaction means in plain words
Colesevelam and Glipizide-metformin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Colesevelam belongs to Endocrine; Glipizide-metformin belongs to Endocrine.
Why it happens
Bile acid sequestrant binds sulfonylurea in the gastrointestinal tract, reducing absorption.
What to do
Give glipizide at least 4 hours before colesevelam. Monitor blood glucose when starting or stopping colesevelam.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Glipizide-metformin
Other interactions of Colesevelam
- Amlodipine-olmesartan-hydrochlorothiazide + Colesevelam Moderate
- Amlodipine-olmesartan + Colesevelam Moderate
- Chenodiol + Colesevelam Moderate
- Cholic acid + Colesevelam Moderate
- Colesevelam + Cyclosporin Moderate
- Colesevelam + Glibenclamide Moderate
Frequently asked questions
Can I take Colesevelam with Glipizide-metformin?
MediHelp rates the interaction as moderate. Colesevelam and Glipizide-metformin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Colesevelam can bind glipizide in the gut and lower its absorption when taken together. Colesevelam also lowers glucose and may add to the effect of the antidiabetic drugs, and it can reduce metformin ER absorption.
How serious is the interaction between Colesevelam and Glipizide-metformin?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Give glipizide at least 4 hours before colesevelam. Monitor blood glucose when starting or stopping colesevelam.
What other medicines interact with Glipizide-metformin?
MediHelp also lists interactions of Glipizide-metformin with, for example, Contrast media, Diatrizoate meglumine / diatrizoate, Diatrizoate. The full list is on the Glipizide-metformin page.
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