Drug interactions
Colesevelam + Glyburide-metformin
Severity: Moderate
Colesevelam and Glyburide-metformin: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Colesevelam binds glyburide in the gut and lowers its absorption when taken together. Separating the doses avoids the reduction. Colesevelam also lowers glucose and may help glycemic control.
What this interaction means in plain words
Colesevelam and Glyburide-metformin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Colesevelam belongs to Endocrine; Glyburide-metformin belongs to Endocrine.
Why it happens
Colesevelam is a bile acid sequestrant that binds glyburide in the gastrointestinal tract and reduces absorption.
What to do
Give glyburide-metformin at least 4 hours before colesevelam. Monitor blood glucose if timing cannot be separated.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
Pro+ members
Unlock the full page
Create an account and start a Pro+ trial to unlock the full management advice for Colesevelam and Glyburide-metformin, the additional notes, the evidence detail and the whole-prescription interaction checker.
- Full clinical management advice
- Additional notes
- Evidence detail
- Interaction checker for a whole prescription
Try Pro+ free for 7 days on the web. No card needed.
Other interactions of Glyburide-metformin
Other interactions of Colesevelam
- Amlodipine-olmesartan-hydrochlorothiazide + Colesevelam Moderate
- Amlodipine-olmesartan + Colesevelam Moderate
- Chenodiol + Colesevelam Moderate
- Cholic acid + Colesevelam Moderate
- Colesevelam + Cyclosporin Moderate
- Colesevelam + Glibenclamide Moderate
Frequently asked questions
Can I take Colesevelam with Glyburide-metformin?
MediHelp rates the interaction as moderate. Colesevelam and Glyburide-metformin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Colesevelam binds glyburide in the gut and lowers its absorption when taken together. Separating the doses avoids the reduction. Colesevelam also lowers glucose and may help glycemic control.
How serious is the interaction between Colesevelam and Glyburide-metformin?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Give glyburide-metformin at least 4 hours before colesevelam. Monitor blood glucose if timing cannot be separated.
What other medicines interact with Glyburide-metformin?
MediHelp also lists interactions of Glyburide-metformin with, for example, Bosentan, Cholic acid, Clarithromycin. The full list is on the Glyburide-metformin page.
Full monographs, dosing and an interaction checker in the MediHelp app
Open the complete reference, check multi-drug interactions and use dosing tools in the MediHelp app.
