Drug interactions
Colesevelam + Metformin-repaglinide
Severity: Minor
Colesevelam and Metformin-repaglinide: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Colesevelam lowers glucose modestly and is used in diabetes, but as a bile acid sequestrant it can bind other drugs in the gut. Data suggest limited effect on metformin, with some reports of altered extended-release metformin exposure. Repaglinide absorption could theoretically be reduced.
What this interaction means in plain words
Colesevelam and Metformin-repaglinide have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Colesevelam belongs to Endocrine; Metformin-repaglinide belongs to Endocrine.
Why it happens
Possible binding of co-administered drugs in the gastrointestinal tract, reducing absorption.
What to do
Take other oral drugs at least 4 hours before colesevelam if absorption is a concern, and monitor glucose.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Metformin-repaglinide
Other interactions of Colesevelam
- Amlodipine-olmesartan-hydrochlorothiazide + Colesevelam Moderate
- Amlodipine-olmesartan + Colesevelam Moderate
- Chenodiol + Colesevelam Moderate
- Cholic acid + Colesevelam Moderate
- Colesevelam + Cyclosporin Moderate
- Colesevelam + Glibenclamide Moderate
Frequently asked questions
Can I take Colesevelam with Metformin-repaglinide?
MediHelp rates the interaction as minor. Colesevelam and Metformin-repaglinide have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Colesevelam lowers glucose modestly and is used in diabetes, but as a bile acid sequestrant it can bind other drugs in the gut. Data suggest limited effect on metformin, with some reports of altered extended-release metformin exposure. Repaglinide absorption could theoretically be reduced.
How serious is the interaction between Colesevelam and Metformin-repaglinide?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Take other oral drugs at least 4 hours before colesevelam if absorption is a concern, and monitor glucose.
What other medicines interact with Metformin-repaglinide?
MediHelp also lists interactions of Metformin-repaglinide with, for example, Gemfibrozil, Apalutamide, Clarithromycin. The full list is on the Metformin-repaglinide page.
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