Drug interactions
Colesevelam + Paricalcitol
Severity: Minor
Colesevelam and Paricalcitol: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Bile acid sequestrants may reduce absorption of fat-soluble vitamin D analogs, potentially lessening the effect of oral paricalcitol on PTH suppression.
What this interaction means in plain words
Colesevelam and Paricalcitol have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Colesevelam belongs to Endocrine; Paricalcitol belongs to Musculoskeletal.
Why it happens
Colesevelam binds the lipophilic vitamin D analog in the gut and may reduce bile-dependent absorption.
What to do
Separate paricalcitol from colesevelam by at least 4 hours and monitor PTH and calcium.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Colesevelam
- Amlodipine-olmesartan-hydrochlorothiazide + Colesevelam Moderate
- Amlodipine-olmesartan + Colesevelam Moderate
- Chenodiol + Colesevelam Moderate
- Cholic acid + Colesevelam Moderate
- Colesevelam + Cyclosporin Moderate
- Colesevelam + Cyclosporine Moderate
Other interactions of Paricalcitol
- Carbamazepine + Paricalcitol Moderate
- Cholestyramine + Paricalcitol Moderate
- Clarithromycin + Paricalcitol Moderate
- Digoxin + Paricalcitol Moderate
- Ketoconazole + Paricalcitol Moderate
- Paricalcitol + Posaconazole Moderate
Frequently asked questions
Can I take Colesevelam with Paricalcitol?
MediHelp rates the interaction as minor. Colesevelam and Paricalcitol have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Bile acid sequestrants may reduce absorption of fat-soluble vitamin D analogs, potentially lessening the effect of oral paricalcitol on PTH suppression.
How serious is the interaction between Colesevelam and Paricalcitol?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Separate paricalcitol from colesevelam by at least 4 hours and monitor PTH and calcium.
What other medicines interact with Colesevelam?
MediHelp also lists interactions of Colesevelam with, for example, Amlodipine-olmesartan-hydrochlorothiazide, Amlodipine-olmesartan, Chenodiol. The full list is on the Colesevelam page.
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