Drug interactions
Colestipol + Digoxin
Severity: Moderate
Colestipol and Digoxin: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Colestipol is a bile acid sequestrant that can bind oral digoxin in the gut and reduce how much is absorbed. This may lower serum digoxin concentrations and weaken its effect on heart rate control or heart failure symptoms.
What this interaction means in plain words
Colestipol and Digoxin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Colestipol belongs to Cardiovascular; Digoxin belongs to Cardiovascular.
Why it happens
Colestipol binds digoxin in the gastrointestinal tract, reducing its oral absorption.
What to do
Give oral digoxin at least 2 hours before or 6 hours after colestipol. Monitor heart rate, clinical response and serum digoxin levels if the regimen changes.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Digoxin
- Digoxin + Lily of the valley Contraindicated
- Digoxin + Squill Contraindicated
- Adagrasib + Digoxin Major
- Amiodarone + Digoxin Major
- Amlodipine-hydrochlorothiazide-valsartan + Digoxin Major
- Amphotericin b deoxycholate + Digoxin Major
Other interactions of Colestipol
- Amlodipine-hydrochlorothiazide-valsartan + Colestipol Moderate
- Amlodipine-olmesartan-hydrochlorothiazide + Colestipol Moderate
- Atenolol-chlorthalidone + Colestipol Moderate
- Azilsartan-chlorthalidone + Colestipol Moderate
- Candesartan-hydrochlorothiazide + Colestipol Moderate
- Captopril-hydrochlorothiazide + Colestipol Moderate
Frequently asked questions
Can I take Colestipol with Digoxin?
MediHelp rates the interaction as moderate. Colestipol and Digoxin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Colestipol is a bile acid sequestrant that can bind oral digoxin in the gut and reduce how much is absorbed. This may lower serum digoxin concentrations and weaken its effect on heart rate control or heart failure symptoms.
How serious is the interaction between Colestipol and Digoxin?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Give oral digoxin at least 2 hours before or 6 hours after colestipol. Monitor heart rate, clinical response and serum digoxin levels if the regimen changes.
What other medicines interact with Digoxin?
MediHelp also lists interactions of Digoxin with, for example, Lily of the valley, Squill, Adagrasib. The full list is on the Digoxin page.
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